Increased Cervical Cancer Risk Associated With Screening at Longer Intervals
The 2012 national recommendations for cervical
cancer screening will produce a lower level of cervical cancer protection than
previously afforded by annual cytology or 3-year cotesting. After a single
negative cotest result, the risk of cervical cancer is twice as large at 5
years as it is at 3 years. Modeling published since the 2012 guidelines were
drafted indicates that extending the cotesting screening interval from 3 to 5
years at ages 30–64 years will result in an additional 1 woman in 369 compliant
with screening receiving a cervical cancer diagnosis during her lifetime, and
an additional 1 in 1,639 dying of cervical cancer. The authors believe that a
significant number of patients and providers would not choose to accept these
additional risks if they understood them, despite the recognition of potential
harms associated with more intensive screening.
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