It has been speculated that the majority of
individuals in the India are deficient in Vitamin D and that Vitamin D deficiency
has become an epidemic in our country. There is widespread prevalence of
varying degrees (50- 90%) of Vitamin D deficiency with low dietary calcium
intake in Indian population according to various studies published earlier. A
deficiency of Vitamin D not only causes poor bone mineralization but also has
been implicated in numerous us chronic diseases. Vitamin D deficiency is common
in women with polycystic ovary syndrome (PCOS),
with the 67-85% of women with PCOS having
serum concentrations of 25-hydroxy Vitamin D (25OHD) <20 ng/ml. Vitamin D
deficiency may intensify symptoms of PCOS, with observational studies showing
lower 25OHD levels were associated with insulin resistance, ovulatory and
menstrual irregularities, lower pregnancy success rate,hirsutism,
hyper-androgenism, obesity and elevated cardiovascular disease risk factors.
There is some, but limited,evidence for beneficial effects of Vitamin D
supplementation on menstrual dysfunction and insulin resistance in women with
PCOS. Vitamin D deficiency may play a role in exacerbating PCOS, and there may
be a place for Vitamin D supplementation in the management of this syndrome,
but current evidence is limited and additional randomized controlled trials are
required to confirm the potential benefits of Vitamin D supplementation in this
population.
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